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Contraindicated (one)pentobarbital will decrease the level or effect of lumefantrine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration with sturdy CYP3A4 inducers may result in reduced serum concentrations and loss of antimalarial efficacyWatch Intently (two)pentobarbital will lessen the level or effect of